PDRN Serum Explained: What "Salmon DNA" Skincare Is and How to Use It

PDRN is one of the biggest skincare trends coming out of Korea. You might have heard of it as "salmon DNA skincare" or seen it in clinic treatments. Now PDRN has moved into everyday serums. This guide explains what PDRN is, where it comes from, how it differs from polynucleotides, and how to use a PDRN serum at home.

What Is PDRN?

PDRN stands for polydeoxyribonucleotide. It is made of DNA fragments, usually extracted and purified from salmon. Salmon is used because its DNA is very similar in structure to human DNA and can be purified to a high degree.

PDRN first became known in professional treatments in Korean dermatology clinics. Today it is a popular ingredient in at-home serums, creams and masks, used for hydrated, radiant-looking skin.

PDRN vs. Polynucleotides (PN)

You may see both terms. They are related:

• PDRN consists of shorter DNA fragments.
• PN (polynucleotides) consists of longer chains.

In everyday skincare, both are used for the same reason: as hydrating, skin-conditioning ingredients for a fresh, healthy-looking glow. In marketing, the terms are sometimes used interchangeably.

Why Is PDRN So Popular?

• It comes from the Korean "glass skin" trend, which focuses on hydrated, luminous skin.
• It is associated with professional clinic treatments, now available in a simple serum.
• It is gentle and fits into almost any routine.
• It pairs naturally with hydrating ingredients like hyaluronic acid.

What Else Is in a Good PDRN Serum?

• Sodium hyaluronate (hyaluronic acid) to bind water in the skin's surface
• Panthenol (provitamin B5) for a soft, comfortable skin feel
• Sodium PCA, part of the skin's natural moisturizing factors
• Peptides such as acetyl hexapeptide-8 for a smoother-looking surface

How to Use a PDRN Serum

1. Cleanse your face.
2. Optional: apply toner.
3. Apply 2 to 4 pumps of PDRN serum to face and neck and massage until absorbed.
4. Follow with moisturizer.
5. In the morning, finish with sunscreen.

PDRN serums are usually used twice a day. They work well under or next to vitamin C, niacinamide and retinol.

Who Should Be Careful?

• Fish allergy: PDRN is usually salmon-derived. If you are allergic to fish, avoid it or ask your doctor.
• Vegans: salmon-derived PDRN is not vegan.
• Do not use on broken or irritated skin.

Checklist Before You Buy

• Is polydeoxyribonucleotide on the ingredient list?
• Is the source (salmon) stated?
• Does it contain supporting hydrators like hyaluronic acid?
• Is it fragrance-free and alcohol-free?
• Is it made in a GMP or ISO 22716-certified facility?

Our PDRN Serum

SUPPLI-X PolyGlow PDRN Serum combines salmon-derived PDRN with acetyl hexapeptide-8, sodium hyaluronate, panthenol and sodium PCA. Lightweight, fragrance-free, with no parabens, sulfates, silicones, mineral oil, phthalates or alcohol. 30 ml, made in the USA in an ISO 22716-certified facility. Contains fish.

Pair it with our Hyaluronic Acid Serum for maximum hydration.

See PolyGlow PDRN Serum →

FAQ

What is PDRN in skincare?

PDRN (polydeoxyribonucleotide) is made of purified DNA fragments, usually from salmon. It is used in skincare for hydrated, radiant-looking skin.

Is PDRN the same as salmon DNA?

Yes, PDRN is usually extracted from salmon DNA and purified for use in skincare.

Is PDRN serum vegan?

No. Salmon-derived PDRN is an animal ingredient and contains fish.

Can I use PDRN with retinol or vitamin C?

Yes. PDRN is gentle and fits well into routines with retinol, vitamin C and niacinamide.

For external use only. Avoid contact with eyes. Do not use on broken skin. Discontinue use if irritation occurs. Contains fish.